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KMID : 1137020070180010008
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Journal of Gynecologic Oncology
2007 Volume.18 No. 1 p.8 ~ p.16
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The annexin 2 expression in invasive cervical cancer
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Moon Hye-Sung
Lee Yu-Sun
Chung Hye-Won
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Abstract
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Objective: The aim of this study was to determine annexin II expression in cervical cancer.
Methods: In Ewha Womans University Mokdong Hospital, normal and cervical cancer tissues were obtained from healthy women (n=11), from patients with cervical intraepithelial neoplasia (CIN, n=11) and from patients with cervical cancer (n=33). The expressions of annexin II mRNA and protein were examined by quantitative competitive-PCR and by western blot analysis. Annexin II mRNA and protein expressions were examined with repects to the clinical characteristics including tumor sizes and cancer stages.
Results: The expression of annexin II mRNA in cervical cancer was higher than that in the normal cervix, and CIN (p<0.05). Annexin II mRNA expression was not correlated with cervical cancer stage, or size of the tumor (p>0.05). The expression of annexin II protein in cervical cancer was higher than that in CIN but its expression was decreased according to the cervical cancer stage.
Conclusion: Our results suggest that overexpression of annexin II mRNA and protein may be a biologic marker of cervical carcinogenesis.
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KEYWORD
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Cervical cancer, Annexin 2
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